Res bsanp resveratrol albumin nanoparticles / albumin nanoparticles carrier encapsulated with taxanes

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RES-BSANP Preparation of resveratrol albumin nanoparticles ：

Take bovine serum albumin (BSA) As a carrier , Desolvate with - Resveratrol albumin nanoparticles were prepared by chemical crosslinking (RES-BSANP). With atomic mechanics microscope (AFM) Observe its shape , Use high performance liquid chromatography (HPLC) Analyze the prepared nanoparticles . Using tetramethylazozolium salt micro enzyme reaction colorimetry (MTT) And flow cytometry (FCM) Compare RES-BSANP Effect on cell cycle . It turns out that , To obtain the RES-BSANP The average particle size of nanoparticles is 400~500 nm, A smooth surface ,12 mg In nanoparticles RES by 4.077 mg, Encapsulation efficiency 33.97%,24 h Good internal stability , Water soluble RES Significantly improve .

Study on albumin nanoparticles coated with taxanes ：

Paclitaxel (Paclitaxel,PTX) Mainly by binding free tubulin , Break the dynamic balance between microtubules and tubulin dimers , Thus inhibiting cell division and proliferation , Play a role .Abraxane With human serum albumin as carrier , It's non-toxic 、 No immunogenicity 、 Good biocompatibility and biodegradability . The common preparation methods of albumin nanoparticles are desolvation 、 Emulsion curing method 、pH- Coagulation method and nab technology . But these methods add methanol in the preparation process 、 Dichloromethane and other organic solvents , There are side effects 、 The preparation process is cumbersome .

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Ruixi YWX.2022.7.19