Preparation of dox-bsanp doxorubicin albumin nanoparticles / platinum loaded albumin nanoparticles targeting EGFR

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DOX-BSANP Preparation of doxorubicin albumin nanoparticles ：

Doxorubicin bovine serum albumin was prepared by desolvation and emulsification crosslinking methods respectively (BSA) Nanoparticles , With BSA yield , Encapsulation efficiency , And particle size are the evaluation indexes , Optimize the prescription process , And compare the differences between the two preparation processes . It turns out that , The appearance of nanoparticles obtained by desolvation and emulsification crosslinking methods is spherical , Little difference ,BSA yield , Encapsulation efficiency , The particle size and potential are 96.5%,92.9%,98.5%,97.4%,4.3%,3.6%,132.4,172.9 nm,-27.7,-19.9 mV. However, the preparation process has a great influence on the release behavior in vitro and the pharmacokinetics behavior in rats , Doxorubicin prepared by desolvation and emulsion crosslinking BSA Nanoparticles in normal saline 48 h The cumulative release rates are 44.2%,63.8%.

Targeting EGFR Preparation of platinum loaded albumin nanoparticles ：

Platinum loaded with albumin , With polyethylene glycol (PEG) It is a dispersion crosslinking agent , With amination EGFR Aptamers act as targeted modifiers , Make soluble albumin nano (Apt-PtNPs) Preparations .

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Ruixi YWX.2022.7.19