Resolution of PIP installation dependency failure

A new one has been built. virtual env, An error occurs when installing the dependency of a project ：

$ pip install -r requirements.txt 
Collecting setuptools==3.4.4 (from -r requirements.txt (line 1))
  Could not fetch URL https://pypi.python.org/simple/setuptools/: There was a problem confirming the ssl certificate: [SSL: TLSV1_ALERT_PROTOCOL_VERSION] tlsv1 alert protocol version (_ssl.c:590) - skipping
  Could not find a version that satisfies the requirement setuptools==3.4.4 (from -r requirements.txt (line 1)) (from versions: )
No matching distribution found for setuptools==3.4.4 (from -r requirements.txt (line 1))

my pip Version or 9.0.1, Upgrade to the latest version to solve . But there is another problem when upgrading ：

$ pip install --upgrade pip
Could not fetch URL https://pypi.python.org/simple/pip/: There was a problem confirming the ssl certificate: [SSL: TLSV1_ALERT_PROTOCOL_VERSION] tlsv1 alert protocol version (_ssl.c:590) - skipping
Requirement already up-to-date: pip in /Users/quanlong.huang/workspace/flask/hawkeye-web/lib/python2.7/site-packages

You can download directly instead get-pip.py And install ：

$ wget https://bootstrap.pypa.io/get-pip.py --no-check-certificate
$ python2 get-pip.py