Preparation of albumin sorafenib /gd2o3/cus composite albumin nanoparticles /alb-icg-dox albumin nanoparticles coated with ICG & dox

The scientific research knowledge that Xiaobian recommends to you today is Albumin sorafenib /Gd2O3/CuS Composite albumin nanoparticles /ALB-ICG-DOX Albumin nanoparticles package ICG&DOX The preparation of , Let's see ！

Albumin sorafenib / The preparation of ：

Prepared by chemical crosslinking HSASRFNPs, It was characterized by particle size analyzer and transmission electron microscope , And calculate the loading capacity and encapsulation efficiency . The nanoparticles were observed by fluorescence microscope BEL7402 Intracellular accumulation ,IncuCyte ZOOM Systematic evaluation of nanoparticle pairs BEL7402 Cell proliferation inhibition , Flow cytometry and Western blotting Legal investigation HSASRFNPs Yes BEL7402 The ability of cells . result HSASRFNPs The hydrated particle size of is (75.8±2.6)nm,Zeta Potential is (19.00±1.02)mV, The loading capacity and encapsulation efficiency are (4.23±0.03)% and (92.52±2.40)%, Can be in BEL7402 Intracellular accumulation .

Gd2O3/CuS Preparation of composite albumin nanoparticles ：

Albumin nano reactor was used to synthesize Gd;O;/CuS Two component composite nanoparticles , Studies have found that in composite nanoparticles Gd/Cu The ratio can effectively control its longitudinal relaxation coefficient , Its MRI performance is several times that of Gd-DTPA. meanwhile , Near infrared fluorescent probes can be modified on the surface of proteins by chemical coupling Cy7.5, obtain Cy7.5-Gd;O;/CuS Nanoparticles , Realize multimodal imaging of near-infrared fluorescence imaging and magnetic resonance imaging .

Related products

Sulfo-NHS Rhodamine, a fluorescent dye B(RhB) Covalently coupled to bovine serum albumin (BSA)

SF-AuNPs Silk fibroin modified gold nanoparticles

Platinum nanoparticles bovine serum albumin [email protected]

BSA-AuNCs  Bovine serum albumin coated gold nanoclusters

Bovine serum albumin modified PEG-PLA Polymer nanoparticles

GNRs-BSA Bovine serum albumin modification GNRs Nanoparticles

Bovine serum albumin surface modified magnetic ferrite nanoparticles

Bovine serum albumin BSA Chitosan - Carboxymethyl konjak (CS-CKGM) Nano microspheres

Ruixi YWX.2022.7.21