Synthesis of tetramethyl rhodamine TRITC modified peptide nucleic acid PNA | TRITC PNA | fluorescein labeled PNA

Tetramethylrhodamine TRITC Modified peptide nucleic acid PNA|TRITC-PNA| Fluorescein labeling PNA Synthesis method

Peptide nucleic acid , Also known as PNA (Peptide Nucleic Acid), yes - A class of novel nucleic acid analogues , Its characteristics are : 1. The ability of writing with nucleic acids is stronger than that of hybridization between nucleic acids ; 2. The thermal stability is higher than that of hybrids between nucleic acids ; 3. The anti enzymatic hydrolysis ability is enhanced , Because of its non peptide and non nucleic acid structural characteristics , Neither protease nor nuclease can degrade peptide nucleic acid (PNA). at present , Peptide nucleic acid (PNA) It is widely used in Chemistry 、 biology 、 Antisense drugs 、 Molecular recognition 、 Genetic diagnosis and other fields . At present, many non classical peptide nucleic acids are also developed , Such as gamma-PN etc. .

The role of fluorescent labeling

  Study on the function of fluorescent marker in protein 、 Drug screening and other fields are also widely used . People use fluorescent labeled peptides to detect the activity of target proteins , The developed high-throughput activity screening method is applied to drug screening and drug development of disease treatment target proteins （ for example , Various kinases 、 Phosphatase 、 Peptidase, etc ）. therefore , Fluorescent modification of polypeptides , It is also an important content in the field of peptide synthesis

Peptide nucleic acid pna Custom products ：

5-TAMRA Labeled peptide nucleic acid PNA
Cy3 Labeled peptide nucleic acid PNA
TRITC Labeled peptide nucleic acid PNA
HEX Labeled peptide nucleic acid PNA
PNA Covalently linked to L Zeolite nanocrystals
PNA Disulfide bond covalently linked porous silica nanoparticles (MSNP)PNA-SS-MSNP
PNA Coupled cell penetrating peptide PNA-CPP
2-Ome Embellished RNA
Cy5 Dye marked PNA(Cy5-PNA
Biotin-PNA
FITC-PNA
5-FAM-PNA
Dansyl-PNA
TMR-（TAMRA-）-PNA
Biotin-Ahx-PNA
FITC-Ahx-PNA
5-FAM-Ahx-PNA
Dansyl-Ahx-PNA
TMR-Ahx-（TAMRA-Ahx-）-PNA
TRITC-PNA
6-FAM/6--PNA
ICG-PNA
CY3-PNA
CY5-PNA
CY5.5-PNA
CY7-PNA
CY7.5-PNA
rhodamine B-PNA
Biotin modification pna Peptide nucleus

Qi Yue bio Small make up axc.2020.07.19