Preparation of GL hsanps glycyrrhizic acid coupled human serum albumin loaded resveratrol / Rhein phospholipid complex serum protein nanoparticles

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GL-HSANPs  Preparation of liver targeting resveratrol encapsulated in glycyrrhizic acid coupled human serum albumin ：

Resveratrol (Resveratrol,RES) It is a non flavonoid polyphenol compound containing stilbene structure , But resveratrol has poor water solubility , Poor stability , Low bioavailability , The short half-life in vivo and other characteristics limit its good biological activity in vivo. Glycyrrhizic acid and human serum albumin are coupled into nanoparticle carriers (GL-HSANPs), Can increase active targeting . Further, the high-pressure homogeneous emulsification method was used to realize the encapsulation of resveratrol , Glycyrrhizic acid coupled resveratrol albumin nanoparticles were prepared (GL-HSA-RESNPs), The purpose is to prepare active targeting RES Nano targeted preparation , At the same time improve RES Bioavailability . Combined with nanotechnology research to prepare GL-HSA-RESNPs Nanoparticles .

Preparation method of Rhein phospholipid complex albumin nanoparticles ：

  Rhein phospholipid complex was prepared by solvent evaporation ; With human serum albumin as carrier , Rhein phospholipid complex albumin nanoparticles were prepared by ultrasonic method . In terms of particle size and polydispersity coefficient (PDI) Optimize the formulation and preparation process of nanoparticles for the main inspection indexes ; The morphology and structure were characterized by laser particle size analyzer and transmission electron microscope ; The encapsulation efficiency and drug loading of nanoparticles were determined by dextran gel column method . result Rhein phospholipid complex albumin nanoparticles were successfully prepared , Its average particle size (156.4±9.8)nm,PDI by (0.180±0.015),Zeta Potential is (-13.8±0.97)mV, The encapsulation rate is (90.38±1.78)%, The loading capacity is (4.14±0.16)%.

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Ruixi YWX.2022.7.18