Collagen protease loaded albumin composite nanoparticles / bovine serum albumin coated ceria nano artificial enzyme

Study on bovine serum albumin encapsulated cerium dioxide nano artificial enzyme ：

The introduction of artificial enzymes can eliminate the defects of natural enzymes , So as to expand the application of enzymes . Bovine serum albumin was synthesized in one step - Ceria nanomaterials , And evaluate the activity of its simulated enzyme . The following research work has been carried out :1. Bovine serum albumin can be synthesized in one step by simple mixing and stirring at room temperature - Ceria nanocomposites , And through ultraviolet visible spectrum , Transmission electron microscope , Fourier transform mid infrared spectroscopy ,X X-ray diffraction characterization ,X X-ray photoelectron spectroscopy , Thermogravimetric analysis and other conventional means have proved the synthesis of nanocomposites , And its average particle size is 2.29 nm,X X-ray diffraction showed that bovine serum albumin - Cerium dioxide is fluorite cubic structure .

The electromotive force measured under neutral condition is -25 mV. after X X-ray photoelectron spectroscopy shows , Bovine serum albumin - Cerium in ceria nanocomposites is Ce3+ and Ce4+ Coexist , And Ce3+ The concentration is 44% about .2. The steady-state kinetic analysis of simulated oxidase of nano materials is studied . It is known that its Michaelis constant is 0.0544 mM, Compared with horseradish peroxidase acting on the same substrate , For substrate 3,3,,5,5,- Tetramethylbenzidine (TMB) Have stronger affinity . Unlike natural enzymes , Bovine serum albumin - Ceria nanomaterials have good stability . Ruixi Xiaobian finished here first .

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RXYWX.2022.7.21